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Article

Estimating the Ages of Selection Signals from Different Epochs in Human History.

Molecular biology and evolution - 1 Mar 2016

Nakagome Shigeki, Alkorta-Aranburu Gorka, Amato Roberto, Howie Bryan, Peter Benjamin M, Hudson Richard R, Di Rienzo Anna

Abstract excerpt

Genetic variation harbors signatures of natural selection driven by selective pressures that are often unknown. Estimating the ages of selection signals may allow reconstructing the history of environmental changes that shaped human phenotypes and diseases. We have developed an approximate Bayesian computation (ABC) approach to estimate allele ages under a model of selection on new mutations and under demographic...

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Identifiers

PMID: 26545921
DOI: 10.1093/molbev/msv256
PMCID: PMC5009997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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