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Article

Genomic instability induced by mutations in Saccharomyces cerevisiae POL1.

Genetics - 1 Sept 2003

Gutiérrez Pedro J A, Wang Teresa S-F

Abstract excerpt

Mutations of chromosome replication genes can be one of the early events that promote genomic instability. Among genes that are involved in chromosomal replication, DNA polymerase alpha is essential for initiation of replication and lagging-strand synthesis. Here we examined the effect of two mutations in S. cerevisiae POL1, pol1-1 and pol1-17, on a microsatellite (GT)(16) tract. The pol1-17 mutation elevated the...

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Identifiers

PMID: 14504218
DOI: 10.1093/genetics/165.1.65
PMCID: PMC1462734

Genes

RAD52

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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