Article
Overexpression of peroxisome proliferator-activated receptor-alpha (PPARalpha)-regulated genes in liver in the absence of peroxisome proliferation in mice deficient in both L- and D-forms of enoyl-CoA hydratase/dehydrogenase enzymes of peroxisomal beta-oxidation system.
The Journal of biological chemistry - 21 Nov 2003
Jia Yuzhi, Qi Chao, Zhang Zhongyi, Hashimoto Takashi, Rao M Sambasiva, Huyghe Steven, Suzuki Yasuyuki, Van Veldhoven Paul P, Baes Myriam, Reddy Janardan K
Abstract excerpt
Peroxisomal beta-oxidation system consists of peroxisome proliferator-activated receptor alpha (PPARalpha)-inducible pathway capable of catalyzing straight-chain acyl-CoAs and a second noninducible pathway catalyzing the oxidation of 2-methyl-branched fatty acyl-CoAs. Disruption of the inducible beta-oxidation pathway in mice at the level of fatty acyl-CoA oxidase (AOX), the first and rate-limiting enzyme,...
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