Article
Protection against syphilis correlates with specificity of antibodies to the variable regions of Treponema pallidum repeat protein K.
Infection and immunity - 1 Oct 2003
Morgan Cecilia A, Lukehart Sheila A, Van Voorhis Wesley C
Abstract excerpt
Syphilis has been recognized as a disease since the late 1400s, yet there is no practical vaccine available. One impediment to the development of a vaccine is the lack of understanding of multiple reinfections in humans despite the development of robust immune responses during the first episode. It has been shown that the Treponema pallidum repeat protein K (TprK) differs in seven discrete variable (V) regions in...
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