Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BRAF mutations in colorectal carcinoma suggest two entities of microsatellite-unstable tumors.

Cancer - 1 Sept 2005

Lubomierski Nikolaus, Plotz Guido, Wormek Marc, Engels Knut, Kriener Susanne, Trojan Jorg, Jungling Bernd, Zeuzem Stefan, Raedle Jochen

Abstract excerpt

BACKGROUND: Alterations of BRAF have been implicated in the carcinogenesis of colorectal tumors with microsatellite instability (MSI). These alterations were attributed to defective DNA mismatch repair, which underlies MSI. It was the objective of this study to clarify the role of BRAF in colorectal carcinoma with MSI. METHODS: After sequencing for BRAF and KRAS in 82 colorectal tumor samples with or without MSI,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

Share to Neoplasm Proteins

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins B-raf

Source

Identifiers

PMID: 16015629
DOI: 10.1002/cncr.21266

Genes

BRAF
KRAS
MLH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BRAF mutations in colorectal carcinoma suggest two entities of microsatellite-unstable tumors.PMID 16015629Read ↗

Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigeneticsSemantic proximity Read ↗

Role of the BRAF mutations in the microsatellite instability genetic pathway in sporadic colorectal cancer.Semantic proximity Read ↗

BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

Colorectal carcinogenesis: MSI-H versus MSI-L.Semantic proximity Read ↗

Colorectal Cancers with the Uncommon Findings of KRAS Mutation and Microsatellite Instability.Semantic proximity Read ↗

Reduced Likelihood of Metastases in Patients with Microsatellite-Unstable Colorectal CancerSemantic proximity Read ↗

Genetic instability in human mismatch repair deficient cancers.Semantic proximity Read ↗

Microsatellite instability in colorectal cancer.Semantic proximity Read ↗

Microsatellite instability and expression of MLH1 and MSH2 in carcinomas of the small intestineSemantic proximity Read ↗

Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening.Semantic proximity Read ↗

Molecular pathways: microsatellite instability in colorectal cancer: prognostic, predictive, and therapeutic implications.Semantic proximity Read ↗

Sporadic Colorectal Cancers With Microsatellite Instability and Their Possible Origin in Hyperplastic Polyps and Serrated AdenomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.