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Article

Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation.

Genes, chromosomes & cancer - 1 Feb 2004

Domingo Enric, Espín Eloi, Armengol Manel, Oliveira Carla, Pinto Mafalda, Duval Alex, Brennetot Caroline, Seruca Raquel, Hamelin Richard, Yamamoto Hiroyuki, Schwartz Simó

Abstract excerpt

BRAF, a serine/threonine kinase of the RAF family, is a downstream transducer of the RAS-regulated MAPK pathway and signals upstream of MEK1/2 kinases. Recently, activating mutations within BRAF have been reported in a high percentage of melanomas and colorectal carcinomas and shown to have oncogenic capabilities. Further, their association to mismatch-repair-deficient tumors has suggested the involvement of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14695993
DOI: 10.1002/gcc.10310

Genes

BRAF
MLH1
APC
AXIN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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