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Article

Constitutive expression of the nef gene suppresses human immunodeficiency virus type 1 (HIV-1) replication in monocytic cell lines.

Virology - 1 Dec 1992

Tsunetsugu-Yokota Y, Matsuda S, Maekawa M, Saito T, Takemori T, Takebe Y

Abstract excerpt

In order to study the effect of nef gene expression on viral replication in monocytic cells, we established monocytic (U937 and THP-1) cell transfectants constitutively expressing the human immunodeficiency virus type 1 nef gene. We constructed a plasmid expressing the nef gene derived from an infectious clone, NL432, under the control of SR alpha promoter which can drive a high level of gene expression. We found...

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PMID: 1448930
DOI: 10.1016/0042-6822(92)90272-q

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Constitutive expression of the nef gene suppresses human immunodeficiency virus type 1 (HIV-1) replication in monocytic cell lines.PMID 1448930Read ↗

Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cellSemantic proximity Read ↗

Intracellular overexpression of HIV-1 Nef impairs differentiation and maturation of monocytic precursors towards dendritic cells.Semantic proximity Read ↗

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The HIV-1 regulatory protein Nef has a specific function in viral expression in a murine macrophage cell line.Semantic proximity Read ↗

Regulation of HIV-1 gene expression by NF-IL6.Semantic proximity Read ↗

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Repression of human cytomegalovirus major immediate early gene expression in a monocytic cell lineSemantic proximity Read ↗

An Endogenous Inhibitor of Human Immunodeficiency Virus in Human Lymphocytes Is Overcome by the Viral Vif ProteinSemantic proximity Read ↗

In vitro modification of human immunodeficiency virus type 1 (HIV-1) infectivity by the U937 cells.Semantic proximity Read ↗

cis expression of the F12 human immunodeficiency virus (HIV) Nef allele transforms the highly productive NL4-3 HIV type 1 to a replication-defective strain: involvement of both Env gp41 and CD4 intracytoplasmic tails.Semantic proximity Read ↗

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