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Article

Constitutive expression of the nef gene suppresses human immunodeficiency virus type 1 (HIV-1) replication in monocytic cell lines.

Virology - 1 Dec 1992

Tsunetsugu-Yokota Y, Matsuda S, Maekawa M, Saito T, Takemori T, Takebe Y

Abstract excerpt

In order to study the effect of nef gene expression on viral replication in monocytic cells, we established monocytic (U937 and THP-1) cell transfectants constitutively expressing the human immunodeficiency virus type 1 nef gene. We constructed a plasmid expressing the nef gene derived from an infectious clone, NL432, under the control of SR alpha promoter which can drive a high level of gene expression. We found...

Topics

CD4 Antigens
Cell Line
Down-Regulation
Gene Products, nef
Genes, nef
Genetic Variation
HIV-1
Monocytes
Promoter Regions, Genetic
Time Factors
Transfection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virus Replication

nef Gene Products, Human Immunodeficiency Virus

Source

Identifiers

PMID: 1448930
DOI: 10.1016/0042-6822(92)90272-q

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1448930-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Constitutive expression of the nef gene suppresses human immunodeficiency virus type 1 (HIV-1) replication in monocytic cell lines.PMID 1448930Read ↗

Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cellSemantic proximity Read ↗

Intracellular overexpression of HIV-1 Nef impairs differentiation and maturation of monocytic precursors towards dendritic cells.Semantic proximity Read ↗

Negative regulation of human immune deficiency virus replication in monocytes. Distinctions between restricted and latent expression in THP-1 cells.Semantic proximity Read ↗

The HIV-1 regulatory protein Nef has a specific function in viral expression in a murine macrophage cell line.Semantic proximity Read ↗

Regulation of HIV-1 gene expression by NF-IL6.Semantic proximity Read ↗

Both virus and host components are important for the manifestation of a Nef- phenotype in HIV-1 and HIV-2.Semantic proximity Read ↗

Repression of human cytomegalovirus major immediate early gene expression in a monocytic cell lineSemantic proximity Read ↗

An Endogenous Inhibitor of Human Immunodeficiency Virus in Human Lymphocytes Is Overcome by the Viral Vif ProteinSemantic proximity Read ↗

In vitro modification of human immunodeficiency virus type 1 (HIV-1) infectivity by the U937 cells.Semantic proximity Read ↗

cis expression of the F12 human immunodeficiency virus (HIV) Nef allele transforms the highly productive NL4-3 HIV type 1 to a replication-defective strain: involvement of both Env gp41 and CD4 intracytoplasmic tails.Semantic proximity Read ↗

T cells chronically infected with HIV do not contain sufficient Nef to promote CD4 downmodulation in the absence of envelope-mediated effects.Semantic proximity Read ↗

Analysis of Tat function in human immunodeficiency virus type 1-infected low-level-expression cell lines U1 and ACH-2Semantic proximity Read ↗

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