Article
Negative regulation of human immune deficiency virus replication in monocytes. Distinctions between restricted and latent expression in THP-1 cells.
The Journal of experimental medicine - 1 May 1990
Mikovits J A, Raziuddin, Gonda M, Ruta M, Lohrey N C, Kung H F, Ruscetti F W
Abstract excerpt
In THP-1 monocytoid cells infected with HIV, viral expression can be regulated in several ways: (a) latency (no viral expression); (b) restricted expression (chronic low-level viral expression with little or no detectable virus released); and (c) continuous production. In cells with restricted HIV expression, nuclear factor(s) were found that blocked tat-associated DNA binding complex formation, suggesting that...
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