Article
The HIV-1 regulatory protein Nef has a specific function in viral expression in a murine macrophage cell line.
Journal of leukocyte biology - 1 Sept 1994
Murphy K M, Sweet M J, Hume D A
Abstract excerpt
Expression of reporter genes under the control of the HIV-1 long terminal repeat (LTR) was up-regulated in the murine macrophage cell line RAW264 by cotransfection of a plasmid coding for the viral regulatory protein Nef. To determine if a discrete section of the LTR was exclusively responsive to...
Topics
- Acquired Immunodeficiency Syndrome
- Alleles
- Animals
- Base Sequence
- Cell Line
- DNA, Viral
- Fibroblasts
- Gene Expression Regulation, Viral
- Gene Products, nef
- Genes, Reporter
- HIV-1
- Macrophages
- Mice
- Molecular Sequence Data
- Phenotype
- Promoter Regions, Genetic
- Transcriptional Activation
- nef Gene Products, Human Immunodeficiency Virus