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Article

Repression of human cytomegalovirus major immediate early gene expression in a monocytic cell line

1 Feb 1992

Abstract excerpt

We have previously shown that a major site of persistence of human cytomegalovirus (HCMV) in healthy carriers is in peripheral blood monocytes. However, monocytes are difficult to infect in vitro with HCMV, and HCMV gene expression cannot be reproducibly detected in peripheral blood cells of healthy carriers. Here we show that the monocytic cell line THP1 is non-permissive for HCMV infection due to a block in...

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Identifiers

PMID: 1311364
DOI: 10.1099/0022-1317-73-2-433

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