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Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell

1 Jul 1995

Abstract excerpt

We have analyzed the replication of Nef+ and Nef- isogenic human immunodeficiency virus in CEM, HUT78, MT4 lymphoid, and U937 monocytic cell lines. At each passage of infected cells, we have assessed the relative infectivity of the virus particles released in culture media by measuring the number of infections units per nanogram of p24 protein. Values appeared to be 3- to 10-fold higher for the Nef+ virus than...

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PMID: 7539505
DOI: 10.1128/jvi.69.7.4053-4059.1995

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