Article
Complex intrapatient sequence variation in the V1 and V2 hypervariable regions of the HIV-1 gp 120 envelope sequence.
Virology - 1 Dec 1992
Pedroza Martins L, Chenciner N, Wain-Hobson S
Abstract excerpt
Human immunodeficiency virus (HIV) quasi-species fluctuate both in time and in space. In general intrapatient variation is less extensive than interpatient variation. The V1 and V2 hypervariable regions of the envelope gene were analyzed for patient samples harboring highly divergent genomes in other loci. Proviral sequences were amplified by PCR, cloned, and sequenced. It was concluded that intrapatient...
Topics
- Amino Acid Sequence
- Base Sequence
- Child
- Genes, env
- Genetic Variation
- Genome, Viral
- HIV Envelope Protein gp120
- HIV Infections
- HIV-1
- Humans
- Male
- Molecular Sequence Data