Article
Follow-up study of intrahost HIV type 2 variability reveals discontinuous evolution of C2V3 sequences.
AIDS research and human retroviruses - 10 Feb 2001
Esteves A, Piedade J, Santos C, Venenno T, Canas-Ferreira W F, Parreira R
Abstract excerpt
Sequence change dynamics in the highly polymorphic C2V3 region of the envelope glycoprotein gp105 coding sequence of HIV-2 was studied for two HIV-2 seropositive Guinean individuals over a 5-year period. Proviral DNA was amplified by PCR from uncultured peripheral blood mononuclear cells (PBMC), cloned, and sequenced. Amino acid sequence alignment and phylogenetic analysis showed distinct viral populations for...
Topics
- Amino Acid Sequence
- DNA, Viral
- Evolution, Molecular
- Gene Products, env
- Genes, env
- Genetic Variation
- HIV Envelope Protein gp120
- HIV Infections
- HIV-2
- Humans
- Molecular Sequence Data
- Peptide Fragments
- Phylogeny
- Proviruses