Article
Follow-up study of intrahost HIV type 2 variability reveals discontinuous evolution of C2V3 sequences.
AIDS research and human retroviruses - 10 Feb 2001
Esteves A, Piedade J, Santos C, Venenno T, Canas-Ferreira W F, Parreira R
Abstract excerpt
Sequence change dynamics in the highly polymorphic C2V3 region of the envelope glycoprotein gp105 coding sequence of HIV-2 was studied for two HIV-2 seropositive Guinean individuals over a 5-year period. Proviral DNA was amplified by PCR from uncultured peripheral blood mononuclear cells (PBMC), cloned, and sequenced. Amino acid sequence alignment and phylogenetic analysis showed distinct viral populations for...
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