Article
Highly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllers.
Retrovirology - 2 May 2017
de Azevedo Suwellen S D, Caetano Diogo Gama, Côrtes Fernanda H, Teixeira Sylvia L M, Dos Santos Silva Karina, Hoagland Brenda, Grinsztejn Beatriz, Veloso Valdilea G, Morgado Mariza G, Bello Gonzalo
Abstract excerpt
BACKGROUND: Ongoing intra-host HIV-1 evolution has been shown in individuals that naturally suppress the viremia to low levels (HIV controllers) by the analysis of the RNA in plasma compartment. Detection of evolution at the DNA proviral compartment in HIV controllers, however, has been more challenging and the precise correlation between the systemic viral suppression level and rate of reservoir's reseeding in...
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