Article
Concurrent evolution of human immunodeficiency virus type 1 in patients infected from the same source: rate of sequence change and low frequency of inactivating mutations.
Journal of virology - 1 Dec 1990
Balfe P, Simmonds P, Ludlam C A, Bishop J O, Brown A J
Abstract excerpt
Direct sequencing of segments of the envelope gene of human immunodeficiency virus type 1 proviruses in peripheral blood mononuclear cells has revealed that a cohort of hemophiliacs who were infected after exposure to a single common batch of factor VIII share closely related virus strains. Seven...
Topics
- Base Sequence
- Biological Evolution
- Cohort Studies
- Factor VIII
- Genes, Viral
- Genetic Variation
- HIV Envelope Protein gp120
- HIV Seropositivity
- HIV-1
- Hemophilia A
- Humans
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Phylogeny