Article
Intrapatient variability of the human immunodeficiency virus type 2 envelope V3 loop.
AIDS research and human retroviruses - 1 May 1995
Sankalé J L, de la Tour R S, Renjifo B, Siby T, Mboup S, Marlink R G, Essex M E, Kanki P J
Abstract excerpt
Studies of HIV-2 infection have shown lower rates of sexual and perinatal transmission and a prolonged incubation period to AIDS as compared to HIV-1. To evaluate the role of genetic variation in HIV pathogenesis, we studied intrapatient variability in the V3 loop of the HIV-2 envelope gene over time in five seropositive individuals. Proviral sequences derived from uncultured PBMC DNA (n = 102) demonstrated an...
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