Article
Evolution of human immunodeficiency virus type 1 envelope sequences in infected individuals with differing disease progression profiles.
Virology - 15 Feb 1998
Shankarappa R, Gupta P, Learn G H, Rodrigo A G, Rinaldo C R, Gorry M C, Mullins J I, Nara P L, Ehrlich G D
Abstract excerpt
Sequence variation displayed by the human immunodeficiency virus type 1 (HIV-1) has been proposed to be linked to the pathogenesis of acquired immunodeficiency syndrome (AIDS). To assess viral evolution during the course of infection, we evaluated sequence variability in the env variable domains in four HIV-1-infected individuals exhibiting differing profiles of CD4+ T cell decline when followed from...
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