Article
Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases.
Molecular and cellular biology - 1 Dec 1992
Ramirez M, Wek R C, Vazquez de Aldana C R, Jackson B M, Freeman B, Hinnebusch A G
Abstract excerpt
The protein kinase GCN2 stimulates expression of the yeast transcriptional activator GCN4 at the translational level by phosphorylating the alpha subunit of translation initiation factor 2 (eIF-2 alpha) in amino acid-starved cells. Phosphorylation of eIF-2 alpha reduces its activity, allowing rib...
Topics
- Alleles
- Amino Acid Sequence
- Cloning, Molecular
- DNA-Binding Proteins
- Eukaryotic Initiation Factor-2B
- Fungal Proteins
- Genes, Fungal
- Histidine-tRNA Ligase
- Molecular Sequence Data
- Mutation
- Peptide Elongation Factors
- Protein Kinases
- Protein Serine-Threonine Kinases