Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

doi:10.1074/jbc.271.40.24989

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Article

Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

The Journal of biological chemistry - 4 Oct 1996

Zhu S, Sobolev A Y, Wek R C

Abstract excerpt

In yeast, starvation for amino acids stimulates GCN2 phosphorylation of the alpha subunit of eukaryotic initiation factor-2 (eIF-2). Phosphorylation of eIF-2alpha induces the translational expression of GCN4, a transcriptional activator of the general amino acid control pathway. It has been propo...

Topics

Eukaryotic Initiation Factor-2
Histidine-tRNA Ligase
Mutation
Phosphorylation
Precipitin Tests
Protein Kinases
Protein Serine-Threonine Kinases
Recombinant Proteins
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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