In vitro analysis of the dominant negative effect of p53 mutants.

doi:10.1006/jmbi.1998.1897

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Article

In vitro analysis of the dominant negative effect of p53 mutants.

Journal of molecular biology - 14 Aug 1998

Chène P

Abstract excerpt

Missense mutations of the p53 tumour suppressor gene induce the formation of proteins with an altered affinity for DNA. These mutant proteins have either a wild-type or a mutant conformation. It has been established that, on association with wild-type protein, molecules with mutant conformation c...

Topics

Binding Sites
DNA
Genes, Dominant
Genes, p53
Humans
Mutation
Oligodeoxyribonucleotides
Protein Binding
Protein Conformation
Tumor Suppressor Protein p53

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