In vitro analysis of the dominant negative effect of p53 mutants.

Abstract excerpt

Missense mutations of the p53 tumour suppressor gene induce the formation of proteins with an altered affinity for DNA. These mutant proteins have either a wild-type or a mutant conformation. It has been established that, on association with wild-type protein, molecules with mutant conformation can drive the wild-type p53 into a mutant conformation. It is shown here that mutant proteins with a wild-type...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Binding Sites
• Share to DNA
• Share to Genes, Dominant