Article
A recombinant inbred strain analysis of sleep-time responses to several sedative-hypnotics.
Alcoholism, clinical and experimental research - 1 Jun 1992
Wehner J M, Pounder J I, Parham C, Collins A C
Abstract excerpt
The results of previous studies suggested that the sleep-time differential between long-sleep (LS) and short-sleep (SS) mice decreases for a series of sedative-hypnotic drugs as lipid solubility increases. Using the LS x SS recombinant inbred (RI) strains, we have tested whether this relationship...
Topics
- 1-Butanol
- 1-Propanol
- Alcohol Drinking
- Animals
- Barbiturates
- Butanols
- Chloral Hydrate
- Dose-Response Relationship, Drug
- Ethanol
- Female
- Hypnotics and Sedatives
- Mice
- Mice, Inbred Strains
- Models, Genetic
- Phenotype
- Recombination, Genetic
- Sleep Stages
- Species Specificity