Article
YopM inhibits platelet aggregation and is necessary for virulence of Yersinia pestis in mice.
Infection and immunity - 1 Oct 1990
Leung K Y, Reisner B S, Straley S C
Abstract excerpt
In Yersinia pestis KIM there are 11 Yops (yersinial outer membrane proteins) encoded by the low-Ca2+ response virulence plasmid pCD1. Only YopM and YopN are found in easily detectable amounts in the culture medium. In our previous work, we characterized the yopM gene. In the present study, we constructed a YopM- mutant to elucidate the role of YopM in the virulence of Y. pestis. A lacZYA sequence was inserted 126...
Topics
- Animals
- Bacterial Outer Membrane Proteins
- Blotting, Northern
- Blotting, Western
- Cloning, Molecular
- Electrophoresis, Gel, Two-Dimensional
- Female
- Genetic Complementation Test
- Mice
- Mice, Inbred BALB C
- Mutation