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Article

On the molecular basis of ion permeation in the epithelial Na+ channel.

The Journal of general physiology - 1 Jul 1999

Kellenberger S, Hoffmann-Pochon N, Gautschi I, Schneeberger E, Schild L

Abstract excerpt

The epithelial Na+ channel (ENaC) is highly selective for Na+ and Li+ over K+ and is blocked by the diuretic amiloride. ENaC is a heterotetramer made of two alpha, one beta, and one gamma homologous subunits, each subunit comprising two transmembrane segments. Amino acid residues involved in binding of the pore blocker amiloride are located in the pre-M2 segment of beta and gamma subunits, which precedes the...

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Identifiers

PMID: 10398689
DOI: 10.1085/jgp.114.1.13
PMCID: PMC2229642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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