Differentiation of promonocytic U937 subclones into macrophagelike phenotypes regulates a cellular factor(s) which modulates fusion/entry of macrophagetropic human immunodeficiency virus type 1.

Abstract excerpt

Monocytes/macrophages (M/M) and CD4+ T cells are two important targets of human immunodeficiency virus (HIV) infection. Different strains of HIV-1 vary markedly in their abilities to infect cells belonging to the M/M lineage. Macrophagetropic (M-tropic) HIV-1 strains replicate well in primary lym...

Topics

• Cell Differentiation
• Gene Products, env
• HIV-1
• Humans
• Ligands
• Macrophages
• Membrane Fusion
• Monocytes
• Phenotype
• Receptors, CCR5
• Tretinoin
• Tumor Cells, Cultured