Article
Variations in alphoid DNA sequences escape detection of aneuploidy at interphase by FISH technique.
Genomics - 1 Sept 1992
Verma R S, Luke S
Abstract excerpt
The advent of a new staining technique, termed fluorescence in situ hybridization (FISH), allows the rapid identification of the genomic constitution of an individual with aneuploidy even in interphase nuclei through the use of a series of chromosome-specific DNA probes, an approach termed "interphase cytogenetics." However, alphoid DNA sequences of every centromere are polymorphic (heteromorphic), and the number...
Topics
- DNA Probes
- DNA, Satellite
- Diagnostic Errors
- Down Syndrome
- Fluorescence
- Genetic Variation
- Humans
- Interphase
- Nucleic Acid Hybridization