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Article

Variations in alphoid DNA sequences escape detection of aneuploidy at interphase by FISH technique.

Genomics - 1 Sept 1992

Verma R S, Luke S

Abstract excerpt

The advent of a new staining technique, termed fluorescence in situ hybridization (FISH), allows the rapid identification of the genomic constitution of an individual with aneuploidy even in interphase nuclei through the use of a series of chromosome-specific DNA probes, an approach termed "interphase cytogenetics." However, alphoid DNA sequences of every centromere are polymorphic (heteromorphic), and the number...

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PMID: 1427817
DOI: 10.1016/s0888-7543(05)80291-5

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