Centromeric alphoid DNA heteromorphisms of chromosome 21 revealed by FISH-technique.

doi:10.1111/j.1399-0004.1997.tb02426.x

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Article

Centromeric alphoid DNA heteromorphisms of chromosome 21 revealed by FISH-technique.

Clinical genetics - 1 Feb 1997

Verma R S, Batish S D, Gogineni S K, Kleyman S M, Stetka D G

Abstract excerpt

The centromeric heterochromatin of chromosome 21 has been evaluated by the fluorescence in situ hybridization (FISH) technique. It was found that the alphoid DNA sequences of pericentromeric regions of chromosome 21 were highly heteromorphic when a centromeric specific probe was hybridized to the...

Topics

Centromere
Chromatin
Chromosomes, Human, Pair 21
Down Syndrome
Genetic Variation
Genetics, Population
Humans
In Situ Hybridization, Fluorescence

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