Evolutionary consequences of DNA mismatch inhibited repair opportunity.

doi:10.1093/genetics/132.2.567

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Article

Evolutionary consequences of DNA mismatch inhibited repair opportunity.

Genetics - 1 Oct 1992

Stephan W, Langley C H

Abstract excerpt

Double strand breaks (DSBs) are often repaired via homologous recombination. Recombinational repair processes are expected to be influenced by nucleotide heterozygosity through mismatch detection systems. Unrepaired DSBs have severe biological consequences and are often lethal. We show that natur...

Topics

Animals
Biological Evolution
DNA Repair
Genetics, Population
Heterozygote
Homozygote
Models, Genetic
Mutation
Polymorphism, Genetic
Recombination, Genetic
Selection, Genetic

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