Article
Age-dependent variations of human and rat colon myofibroblasts in culture: Influence on their functional interactions with colon cancer cells.
International journal of cancer - 10 Mar 2003
Pourreyron Céline, Dumortier Jérôme, Ratineau Christelle, Nejjari Mimoun, Beatrix Olivier, Jacquier Marie-France, Remy Lionel, Chayvialle Jean-Alain, Scoazec Jean-Yves
Abstract excerpt
Epithelial-mesenchymal interactions play a pivotal role in colon cancer invasion and metastasis. We aimed at elucidating the impact of long-term cultivation on the phenotypic and functional characteristics of primary fibroblasts and their interaction with the human colon adenocarcinoma cell line LoVoC5. We used fibroblasts from human colon tumor tissue, normal human colon mucosa, rat normal colon and 2 rat...
Topics
- Actins
- Adenocarcinoma
- Animals
- Biomarkers
- Cell Adhesion
- Cell Differentiation
- Cell Division
- Cell Size
- Cells, Cultured
- Cellular Senescence
- Coculture Techniques
- Collagen Type I
- Collagen Type IV