Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Rhabdomyosarcoma development in Trp53/fos mutant mice: tumor suppressor functions of the Fos protooncogene].

Verhandlungen der Deutschen Gesellschaft fur Pathologie - 1 Jan 2004

Jochum W

Abstract excerpt

Rhabdomyosarcoma is the most common soft tissue sarcoma in children, yet the genetic changes causing this disease are poorly understood. The Fos protein, a major component of the AP-1 transcription factor, is essential for osteoclast differentiation, acts as an oncogene, potentiates transforming signals and controls invasive growth and angiogenesis during tumor progression. To genetically investigate a potential...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Deletion
Share to Genes, fos
Share to Genes, p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Mice, Mutant Strains

Share to Proto-Oncogene Mas

Share to Proto-Oncogene Proteins c-fos

Share to Rhabdomyosarcoma

Source

Identifiers

PMID: 16892556

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Rhabdomyosarcoma development in Trp53/fos mutant mice: tumor suppressor functions of the Fos protooncogene].PMID 16892556Read ↗

Rhabdomyosarcoma development in mice lacking Trp53 and Fos: tumor suppression by the Fos protooncogene.Semantic proximity Read ↗

Rhabdomyosarcomagenesis-Novel pathway found.Semantic proximity Read ↗

The transcription factor Fos: a Janus-type regulator in health and disease.Semantic proximity Read ↗

Biological and therapeutic insights from animal modeling of fusion-driven pediatric soft tissue sarcomasSemantic proximity Read ↗

PAX3/7-FOXO1 fusion-negative alveolar rhabdomyosarcoma in Schuurs-Hoeijmakers syndrome.Semantic proximity Read ↗

Fusions Involving PAX and FOX Genes in the Molecular Pathogenesis of Alveolar Rhabdomyosarcoma: Recent AdvancesSemantic proximity Read ↗

Identification of a PAX-FKHR Gene Expression Signature that Defines Molecular Classes and Determines the Prognosis of Alveolar RhabdomyosarcomasSemantic proximity Read ↗

<i>Pax</i> genes in embryogenesis and oncogenesisSemantic proximity Read ↗

Defining function of wild-type and three patient-specific TP53 mutations in a zebrafish model of embryonal rhabdomyosarcoma.Semantic proximity Read ↗

A call to ARMS: targeting the<i>PAX3-FOXO1</i>gene in alveolar rhabdomyosarcomaSemantic proximity Read ↗

Trp53 and Rb1 deficiency in chondrocytes spontaneously develop chondrosarcoma by activation of YAP signalingSemantic proximity Read ↗

The role of chimeric paired box transcription factors in the pathogenesis of pediatric rhabdomysarcoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.