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Article

The effect of recombinant IgG antibodies against the leucine-33 form of the platelet beta3 integrin (HPA-1a) on platelet function.

Thrombosis and haemostasis - 1 Apr 2004

Joutsi-Korhonen Lotta, Preston Sandy, Smethurst Peter A, Ijsseldijk Martin, Schaffner-Reckinger Elisabeth, Armour Kathryn L, Watkins Nicholas A, Clark Michael R, de Groot Philip G, Farndale Richard W, Ouwehand Willem H, Williamson Lorna M

Abstract excerpt

Recombinant HPA-1a antibodies with Fc, mutated to remove destructive effector functions, have been developed as a potential therapy for fetomaternal alloimmune thrombocytopenia (FMAIT), via blockade of binding of human HPA-1a polyclonal antibodies to fetal HPA-1a1b platelets. We have assessed the...

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Identifiers

PMID: 15045136
DOI: 10.1160/TH03-07-0484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15045136-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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The effect of recombinant IgG antibodies against the leucine-33 form of the platelet beta3 integrin (HPA-1a) on platelet function.PMID 15045136Read ↗

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