Wild-type murine p53 represses transcription from the murine c-myc promoter in a human glial cell line.

doi:10.1002/jcb.240490213

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Article

Wild-type murine p53 represses transcription from the murine c-myc promoter in a human glial cell line.

Journal of cellular biochemistry - 1 Jun 1992

Moberg K H, Tyndall W A, Hall D J

Abstract excerpt

Here we analyzed the effect of the suppressor proto-oncogene p53 on transcription from the P2 promoter of the murine c-myc gene. c-myc promoter constructs were coupled to the chloramphenicol acetyl-transferase (CAT) gene and were transiently transfected into a human glial cell along with plasmids overexpressing wild-type or mutant p53. It was found that significant repression of c-myc transcription took place...

Topics

Animals
Antigens, Polyomavirus Transforming
Base Sequence
Cell Line
Chloramphenicol O-Acetyltransferase
DNA Mutational Analysis
Genes, Suppressor
Genes, myc
Humans
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neuroglia

Promoter Regions, Genetic

Proto-Oncogene Mas

Recombinant Fusion Proteins

Regulatory Sequences, Nucleic Acid

Suppression, Genetic

Source

Open in PubMed

Identifiers

PMID: 1400626
DOI: 10.1002/jcb.240490213

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1400626-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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