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Article

p53 mutations in formaldehyde-induced nasal squamous cell carcinomas in rats.

Cancer research - 1 Nov 1992

Recio L, Sisk S, Pluta L, Bermudez E, Gross E A, Chen Z, Morgan K, Walker C

Abstract excerpt

Formaldehyde induces squamous cell carcinomas in the nasal passages of rats following chronic inhalation exposure at concentrations of > or = 10 ppm. We have examined the complementary DNA of the tumor suppressor gene p53 from 11 primary formaldehyde-induced tumors for mutation using DNA sequence analysis. A polymerase chain reaction-amplified fragment of the rat p53 complementary DNA containing the...

Topics

Animals
Base Sequence
Carcinoma, Squamous Cell
DNA, Neoplasm
Formaldehyde
Genes, p53
Molecular Sequence Data
Mutation
Nose Neoplasms
Polymerase Chain Reaction
Rats
Rats, Inbred F344

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1394239

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1394239-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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