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Article

Measurement of tumor-associated mutations in the nasal mucosa of rats exposed to varying doses of formaldehyde.

Regulatory toxicology and pharmacology : RTP - 1 Jan 2000

Meng Fanxue, Bermudez Edilberto, McKinzie Page B, Andersen Melvin E, Clewell Harvey J, Parsons Barbara L

Abstract excerpt

This study examined the potential induction of tumor-associated mutations in formaldehyde-exposed rat nasal mucosa using a sensitive method, allele-specific competitive blocker-PCR (ACB-PCR). Levels of p53 codon 271 CGT to CAT and K-Ras codon 12 GGT to GAT mutations were quantified in nasal mucosa of rats exposed to formaldehyde. In addition, nasal mucosa cell proliferation was monitored because regenerative cell...

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Source

Identifiers

PMID: 20347909
DOI: 10.1016/j.yrtph.2010.03.007

Genes

CAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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