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Article

A mutant nuclear protein with similarity to RNA binding proteins interferes with nuclear import in yeast.

Molecular biology of the cell - 1 Aug 1992

Bossie M A, DeHoratius C, Barcelo G, Silver P

Abstract excerpt

We have isolated mutants of the yeast Saccharomyces cerevisiae that are defective in localization of nuclear proteins. Chimeric proteins containing the nuclear localization sequence from SV40 large T-antigen fused to the N-terminus of the mitochondrial F1 beta-ATPase are localized to the nucleus. Npl (nuclear protein localization) mutants were isolated by their ability to grow on glycerol as a consequence of no...

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Identifiers

PMID: 1392078
DOI: 10.1091/mbc.3.8.875
PMCID: PMC275646

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