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Article

The heme-globin and dimerization equilibria of recombinant human hemoglobins carrying site-specific beta chains mutations.

Archives of biochemistry and biophysics - 15 Feb 2001

Gattoni M, Piro M C, Boffi A, Brinigar W S, Fronticelli C, Chiancone E

Abstract excerpt

The heme-globin and dimer-tetramer equilibria of ferric recombinant human hemoglobins with site-specific beta chain mutations at the heme pocket or at either the a1beta1 or the alpha1beta2 interfaces have been determined. The heme pocket mutation V67T leads to a marked stabilization of the beta chain heme and does not affect the dimer-tetramer association constant, K2,4. In the C112 mutants, the intrinsic rate of...

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Identifiers

PMID: 11368339
DOI: 10.1006/abbi.2000.2185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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