Expression of vacuolar H(+)-ATPase in mouse osteoclasts during in vitro differentiation.

doi:10.1152/ajprenal.1992.263.2.F277

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Article

Expression of vacuolar H(+)-ATPase in mouse osteoclasts during in vitro differentiation.

The American journal of physiology - 1 Aug 1992

Wang Z Q, Hemken P, Menton D, Gluck S

Abstract excerpt

Osteoclasts express high levels of a vacuolar H(+)-adenosinetriphosphatase (H(+)-ATPase) on the ruffled membrane which they employ to dissolve bone mineral by acidifying their site of attachment on bone. The factors that control amplification of H(+)-ATPase during osteoclast differentiation are poorly understood. We examined the expression of vacuolar H(+)-ATPase in a cell culture system in which mouse spleen...

Topics

Acid Phosphatase
Animals
Bone Resorption
Cell Differentiation
Cells, Cultured
Cytological Techniques
Dexamethasone
Dihydroxycholecalciferols
Drug Resistance
Genetic Markers
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microscopy, Electron, Scanning

Osteoclasts

Phenotype

Proton-Translocating ATPases

Spleen

Tartrates

Vacuoles

Source

Open in PubMed

Identifiers

PMID: 1387291
DOI: 10.1152/ajprenal.1992.263.2.F277

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1387291-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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