Article
Carbonic anhydrase II and H+ -ATPase in osteoclasts of four osteopetrotic mutations in the rat.
Histochemistry and cell biology - 1 Jan 1999
Sundquist K T, Väänänen H K, Marks S C
Abstract excerpt
Osteopetrosis in laboratory animals is a metabolic bone disease characterized by increased skeletal mass. It is inherited as an autosomal recessive and results from a defect in the development and/or function of osteoclasts. We studied two enzymes essential for bone resorption, carbonic anhydrase II isoenzyme (CA II) and H+ -ATPase, in osteoclasts from four osteopetrotic mutations in the rat; namely...
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