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Article

Mapping of the leptin binding sites and design of a leptin antagonist.

The Journal of biological chemistry - 24 Sept 2004

Peelman Frank, Van Beneden Katrien, Zabeau Lennart, Iserentant Hannes, Ulrichts Peter, Defeau Delphine, Verhee Annick, Catteeuw Dominiek, Elewaut Dirk, Tavernier Jan

Abstract excerpt

The leptin/leptin receptor system shows strong similarities to the long-chain cytokine interleukin-6 (IL-6) and granulocyte colony-stimulating factor cytokine/receptor systems. The IL-6 family cytokines interact with their receptors through three different binding sites I-III. The leptin structure was superposed on the crystal structures of several long-chain cytokines, and a series of leptin mutants was...

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PMID: 15213225
DOI: 10.1074/jbc.M404962200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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