Article
Differential methylation of the hypervariable locus DXS255 on active and inactive X chromosomes correlates with the expression of a human X-linked gene.
Genomics - 1 Jun 1990
Brown R M, Fraser N J, Brown G K
Abstract excerpt
Consistent differences in methylation of particular cytosine residues in the DNA of active and inactive X chromosomes can be used for rapid, direct analysis of X-inactivation patterns in different female tissues. We have studied methylation of the highly polymorphic DXS255 locus in tissues from p...
Topics
- Dosage Compensation, Genetic
- Female
- Gene Expression
- Genetic Linkage
- Humans
- Immunoblotting
- Methylation
- Mutation
- Pyruvate Dehydrogenase Complex Deficiency Disease
- Pyruvate Metabolism, Inborn Errors
- Restriction Mapping
- X Chromosome