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Article

Methylation of HpaII site at the human DXS16 locus on Xp22 as an assay for abnormal patterns of X inactivation.

American journal of medical genetics - 1 Jan 2001

Khalifa M M, Struthers J L, Maurice S, Harrison K, Duncan A M

Abstract excerpt

The highly polymorphic human DXS16 locus on Xp22 contains a BglII restriction fragment length polymorphism with 33% heterozygosity. We report that methylation of the HpaII site, 3.1 kb away from this restriction fragment length polymorphism, correlates with X-inactivation. The BglII polymorphism distinguishes between the maternal and paternal alleles, and HpaII digestion identifies their methylation status. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Deoxyribonucleases, Type II Site-Specific

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Share to Polymorphism, Restriction Fragment Length

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Identifiers

PMID: 11426457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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