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Article

Distinctive polymorphism at the HLA-C locus: implications for the expression of HLA-C.

The Journal of experimental medicine - 1 Oct 1992

Zemmour J, Parham P

Abstract excerpt

The HLA-C locus remains an enigma. The serological polymorphism is poorly defined, HLA-C molecules are expressed at the cell surface at about 10% the levels of HLA-A and -B, and their importance for antigen presentation to either CD8-bearing T cells or natural killer cells is unclear. Our understanding of HLA-C polymorphism has also lagged behind that of HLA-A and -B. We have applied the polymerase chain reaction...

Topics

Alleles
Amino Acid Sequence
Antibody Specificity
B-Lymphocytes
Base Sequence
Cell Line
DNA
Epitopes
HLA-A Antigens
HLA-B Antigens
HLA-C Antigens
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Oligodeoxyribonucleotides

Polymerase Chain Reaction

Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 1383381
DOI: 10.1084/jem.176.4.937
PMCID: PMC2119399

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1383381-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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