Article
HLA class I polymorphism: structure and function and still questions.
Human immunology - 15 Sept 1997
Kostyu D D, Hannick L I, Traweek J L, Ghanayem M, Heilpern D, Dawson D V
Abstract excerpt
The HLA-A, HLA-B and HLA-C molecules have turned out to be highly polymorphic and functionally complex. They not only serve as peptide receptors, but also interact with beta 2-microglobulin, an alpha beta T cell receptor, CD8 and NK inhibitory molecules, all at different sites. The fact that more than 300 class I alleles have now been defined prompted us to ask the question of where polymorphism really occurs in...
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