Article
Polymorphism at the HLA-E locus predates most HLA-A and -B polymorphism.
Human immunology - 1 Mar 1992
Geraghty D E, Stockschleader M, Ishitani A, Hansen J A
Abstract excerpt
The extensive polymorphism of the classic class I antigens has been well described. In contrast, the nonclassic HLA antigens are distinguished by their low polymorphism. We examine here the HLA polymorphism of the HLA-E locus by examining the DNA sequence of cDNA from nine ethnically diverse individuals. From this analysis, we show that there is no polymorphism in the regions including exon 1 and from exon 4 to...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Chromosome Mapping
- Genes, MHC Class I
- HLA Antigens
- HLA-A Antigens
- HLA-B Antigens
- Humans
- Molecular Sequence Data
- Polymorphism, Genetic