Article
Clinical relevance of donor-specific antibodies directed at HLA-C: A long road to acceptance.
HLA - 1 Jan 2021
Visentin Jonathan, Couzi Lionel, Taupin Jean-Luc
Abstract excerpt
In solid organ transplantation (SOT), the clinical relevance of donor-specific antibodies (DSA) directed at anti-HLA-A, -B, -DR and -DQ antigens is largely recognized while it is still a matter of debate for DSA directed at HLA-C. In this review, we summarize the peculiarities of HLA-C among class I HLA antigens as well as their immunogenicity, which underlie the clinical relevance of HLA-C locus and anti-HLA-C...
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