Article
Sequence-based typing provides a new look at HLA-C diversity.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 1998
Turner S, Ellexson M E, Hickman H D, Sidebottom D A, Fernández-Viña M, Confer D L, Hildebrand W H
Abstract excerpt
Although extensive HLA-A and HLA-B polymorphism is evident, the true diversity of HLA-C has remained hidden due to poor resolution of HLA-C Ags. To better understand the polymorphic nature of HLA-C molecules, 1823 samples from the National Marrow Donor Program research repository in North America have been typed by DNA sequencing and interpreted in terms of HLA-C diversification. Results show that HLA-Cw*0701 was...
Topics
- Alleles
- Base Sequence
- DNA
- Genes, MHC Class I
- HLA-C Antigens
- Histocompatibility Testing
- Humans
- Models, Molecular
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Genetic