Article
Experimental co-expression of vimentin and keratin intermediate filaments in human breast cancer cells results in phenotypic interconversion and increased invasive behavior.
The American journal of pathology - 1 Feb 1997
Hendrix M J, Seftor E A, Seftor R E, Trevor K T
Abstract excerpt
The expression of intermediate filament proteins is remarkably tissue specific, which suggests that the intermediate filament type(s) present in cells is somehow related to their biological function. However, in some cancers, particularly malignant breast carcinoma, there is a strong indication t...
Topics
- Animals
- Breast Neoplasms
- Cell Membrane
- Colony-Forming Units Assay
- Humans
- Integrins
- Keratins
- Mice
- Mice, SCID
- Neoplasm Invasiveness
- Neoplasm Transplantation
- Phenotype
- Transplantation, Heterologous
- Tumor Cells, Cultured
- Vimentin