Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nonlinear responses for chromosome and gene level effects induced by vinyl acetate monomer and its metabolite, acetaldehyde in TK6 cells.

Environmental and molecular mutagenesis - 1 Dec 2013

Budinsky Robert, Gollapudi Bhaskar, Albertini Richard J, Valentine Rudolph, Stavanja Mari, Teeguarden Justin, Fensterheim Robert, Rick David, Lardie Thomas, McFadden Lisa, Green Amanda, Recio Leslie

Abstract excerpt

Vinyl acetate monomer (VAM) produced rat nasal tumors at concentrations in the hundreds of parts per million. However, VAM is weakly genotoxic in vitro and shows no genotoxicity in vivo. A European Union Risk Assessment concluded that VAM's hydrolysis to acetaldehyde (AA), via carboxylesterase, is a critical key event in VAM's carcinogenic potential. In the following study, we observed increases in micronuclei...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetaldehyde
Share to Chromosomes, Human

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Damage

Share to Dose-Response Relationship, Drug

Share to Lymphocytes

Share to Micronucleus Tests

Share to Mutagens

Share to Thymidine Kinase

Source

Identifiers

PMID: 24038327
DOI: 10.1002/em.21809

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nonlinear responses for chromosome and gene level effects induced by vinyl acetate monomer and its metabolite, acetaldehyde in TK6 cells.PMID 24038327Read ↗

Evaluation of vinyl laurate in a battery of in vitro and in vivo tests for genotoxicity.Semantic proximity Read ↗

Mutagenicity of vinyl chloride and its reactive metabolites, chloroethylene oxide and chloroacetaldehyde, in a metabolically competent human B-lymphoblastoid line.Semantic proximity Read ↗

Homologous recombination contributes to the repair of acetaldehyde-induced DNA damage.Semantic proximity Read ↗

Mutagenicity of vinyl chloride monomer.Semantic proximity Read ↗

p53 codon 271 CGT to CAT mutant fraction does not increase in nasal respiratory and olfactory epithelia of rats exposed to inhaled naphthalene.Semantic proximity Read ↗

Biomarkers of exposure and effect in human lymphoblastoid TK6 cells following [13C2]-acetaldehyde exposure.Semantic proximity Read ↗

Genotoxicity induced in human lymphoblasts by atmospheric reaction products of naphthalene and phenanthrene.Semantic proximity Read ↗

Homologous recombination contributes to the repair of acetaldehyde-induced DNA damagesSemantic proximity Read ↗

[Susceptibility of chromosomal damage among workers exposed to vinyl chloride monomer].Semantic proximity Read ↗

Ethyl methanesulfonate toxicity in Viracept--a comprehensive human risk assessment based on threshold data for genotoxicity.Semantic proximity Read ↗

Investigations on the in vitro and in vivo genotoxic potential of 5-vinyl-2-norbornene.Semantic proximity Read ↗

Genotoxicity of acrylamide and glycidamide in human lymphoblastoid TK6 cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.