Article
Heteroclitic polyclonal and monoclonal anti-Gm(a) and anti-Gm(g) human rheumatoid factors react with epitopes induced in Gm(a-), Gm(g-) IgG by interaction with antigen or by nonspecific aggregation. A possible mechanism for the in vivo generation of rheumatoid factors.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 1992
Williams R C, Malone C C, Casali P
Abstract excerpt
Heteroclitic rheumatoid factors (RF) are specific for allotypic determinants, e.g., Gm(a) or Gm(g) on allogeneic, but not autologous IgG. All polyclonal RF we isolated from nine rheumatoid arthritis patients with circulating Gm(a-), (b+), (g-), (f+) IgG displayed dual heteroclitic activity for th...
Topics
- Antibodies, Monoclonal
- Arthritis, Rheumatoid
- B-Lymphocytes
- Base Sequence
- Epitopes
- Hot Temperature
- Humans
- Immunoglobulin G
- Immunoglobulin Gm Allotypes
- Molecular Sequence Data
- Phenotype
- Polymerase Chain Reaction
- Protein Conformation