Article
Evidence that stem cell factor is involved in the rebound thrombocytosis that follows 5-fluorouracil treatment.
Blood - 15 Aug 1992
Hunt P, Zsebo K M, Hokom M M, Hornkohl A, Birkett N C, del Castillo J C, Martin F
Abstract excerpt
The mechanisms responsible for 5-fluorouracil (5FU)-induced rebound thrombocytosis are not completely understood. SI/SI(d) mice, which do not undergo rebound thrombocytosis in response to 5FU, provide a genetic approach to the study of this phenomenon. Recent reports by several groups that the SI...
Topics
- Animals
- Bone Marrow
- Fluorouracil
- Gene Expression
- Hematopoietic Cell Growth Factors
- Kinetics
- Megakaryocytes
- Mice
- Mice, Inbred BALB C
- Mutation
- Nucleic Acid Hybridization
- Platelet Count
- Polymerase Chain Reaction
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-kit
- RNA, Messenger
- Receptors, Cell Surface
- Stem Cell Factor