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Article

Evidence that stem cell factor is involved in the rebound thrombocytosis that follows 5-fluorouracil treatment.

Blood - 15 Aug 1992

Hunt P, Zsebo K M, Hokom M M, Hornkohl A, Birkett N C, del Castillo J C, Martin F

Abstract excerpt

The mechanisms responsible for 5-fluorouracil (5FU)-induced rebound thrombocytosis are not completely understood. SI/SI(d) mice, which do not undergo rebound thrombocytosis in response to 5FU, provide a genetic approach to the study of this phenomenon. Recent reports by several groups that the SI locus encodes a protein known variably as stem cell factor (SCF), mast cell growth factor, or kit ligand, suggests the...

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PMID: 1379852

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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