Loss of CD23 is a consequence of B-cell activation. Implications for the analysis of B-cell lineages.

doi:10.1111/j.1749-6632.1992.tb24602.x

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Article

Loss of CD23 is a consequence of B-cell activation. Implications for the analysis of B-cell lineages.

Annals of the New York Academy of Sciences - 4 May 1992

Rabin E, Cong Y Z, Wortis H H

Abstract excerpt

When splenic CD5- B cells are stimulated with antiimmunoglobulin they become CD5+ and have a prolonged in vitro life. Further treatment with IL-6 induces a loss of surface CD23 and IgD; that is, they resemble freshly isolated peritoneal CD5+ cells. These data suggest that the CD5 phenotype is induced after sIg-mediated B-cell activation. Additional support for this view arises from the observation that the loss...

Topics

Animals
Antibody Formation
Antigens, CD
Antigens, Differentiation, B-Lymphocyte
B-Lymphocytes
CD5 Antigens
Cells, Cultured
Flow Cytometry
Immunoglobulin E
Interleukin-6
Lymphocyte Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred CBA

Phenotype

RNA

Receptors, Fc

Receptors, IgE

Spleen

Source

Open in PubMed

Identifiers

PMID: 1376028
DOI: 10.1111/j.1749-6632.1992.tb24602.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1376028-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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